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M9460583.TXT
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1994-06-25
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Document 0583
DOCN M9460583
TI Stable biological and antigenic characteristics of HIV-2SBL6669 in
nonpathogenic infection of macaques.
DT 9408
AU Zhang YJ; Putkonen P; Albert J; Ohman P; Biberfeld G; Fenyo EM;
Department of Virology, Karolinska Institute, Stockholm, Sweden.
SO Virology. 1994 May 1;200(2):583-9. Unique Identifier : AIDSLINE
MED/94233721
AB The purpose of the present study was to investigate if the biological
and antigenic properties of human immunodeficiency virus type 2 change
over time in cynomolgus macaques (Macaca fascicularis) experimentally
infected with HIV-2SBL6669. Sequential virus isolates and serum samples
were obtained during a 2-year period and studied in autologous
neutralization assays. All six macaques studied seroconverted shortly
after infection and remained healthy during the observation period.
Virus could be isolated from all six animals during the first 100 days
postinfection. Thereafter four monkeys became virus isolation negative,
either permanently or transiently (two macaques each), whereas two
macaques remained virus isolation positive during the entire observation
period. Sequential reisolates from the macaques invariably replicated in
HUT-78, U937-2, and Jurkat-tat cell lines, similarly to the HIV-2SBL6669
inoculum virus. The ability to produce neutralizing antibodies
correlated with positive virus isolations, hence four macaques produced
neutralizing antibodies against inoculum virus and sequential
reisolates. Once the neutralizing antibody appeared, sequential
reisolates obtained at both early and late time after infection were
neutralized, indicating that the neutralizing epitopes of the virus are
conserved in the infected animals over time. This is different from the
pathogenic SIVsm infection in macaques or HIV-1 infection in humans,
where emergence of neutralization resistant variants seems to be the
rule. In contrast, in HIV-2-infected macaques the biological properties
of the virus are stable and the neutralizing antibody response shows
extensive cross-reactivity.
DE Animal Human HIV Antibodies/*IMMUNOLOGY HIV Antigens/BLOOD HIV
Infections/*ETIOLOGY HIV Seropositivity
HIV-2/*GENETICS/*IMMUNOLOGY/PATHOGENICITY Leukocyte Count Macaca
fascicularis Neutralization Tests Species Specificity Support,
Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Time Factors T4
Lymphocytes/CYTOLOGY *Variation (Genetics) Virulence Virus
Replication JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).